Title :
Interaction between O2-Hb kinetics and the Fahraeus effect
Author :
Ye, Guo-Fan ; Buerk, Donald G. ; Ye, Lei ; Jaron, Dov
Author_Institution :
Biomed. Eng. & Sci. Inst., Drexel Univ., Philadelphia, PA, USA
Abstract :
The influence of O2-Hb kinetics and the Fahraeus effect on gas transport in the microcirculation was investigated in the steady state using a multicompartmental model for O2-CO2 coupled transport in the cat brain microcirculation. Results suggest that the influence of O2-Hb reaction kinetics on oxygen transport is characterized by two major features: the difference-at the same Po2-between the actual capillary O2-Hb saturation and the equilibrium O2-Hb saturation, and an increase in the value of venous Po2 predicted by the model. The Fahraeus effect results in a Po2 increase in the vein and venules and a Po2 decrease in the tissue and arterioles. The two mechanisms enhance each other. Their interaction is more significant during ischemia
Keywords :
biotransport; brain models; haemorheology; oxygen; physiological models; proteins; CO2; Fahraeus effect; O2; O2-CO2 coupled transport; O2-Hb kinetics; cat brain microcirculation; gas transport; ischemia; microcirculation; multicompartmental model; vein; venules; Art; Biomedical engineering; Blood; Brain modeling; Equations; Ischemic pain; Kinetic theory; Predictive models; Steady-state; Veins;
Conference_Titel :
Engineering in Medicine and Biology Society, 1995., IEEE 17th Annual Conference
Conference_Location :
Montreal, Que.
Print_ISBN :
0-7803-2475-7
DOI :
10.1109/IEMBS.1995.579800
