Ontogeny of the paired-pulse index: a measure of dentate granule cell modulation

Author

Bronzino, J.D. ; Blaise, J.H. ; Austin-LaFrance, R.J. ; Morgane, P.J.

Author_Institution

Dept. of Eng. & Comput. Sci., Trinity Coll., Hartford, CT, USA

Volume

2

fYear

1995

fDate

20-23 Sep 1995

Firstpage

1537

Abstract

In this report the authors present the dentate granule cell population response to paired-pulse stimulation of the perforant path obtained from freely-moving rats at 15, 30, and 90 days of age. The resultant paired-pulse indices (PPIs) indicated that a markedly low level of facilitation and lack of late inhibitory modulation is present in 15 day old rats when compared to the 90 day (adult) group. Values of the PPI obtained from 30 day old rats fall intermediate between the 15 day and adult groups. These results indicate that the PPI can be effectively used as a measure of the maturation of dentate granule cell modulation

Keywords

bioelectric phenomena; brain; cellular biophysics; 0.041 to 0.246 y; dentate granule cell modulation maturation; dentate granule cell modulation measure; freely-moving rats; late inhibitory modulation; paired-pulse index ontogeny; paired-pulse indices; perforant path; Computer science; Coupling circuits; Educational institutions; Embryo; Laboratories; Neuroplasticity; Phase measurement; Pulse measurements; Pulse modulation; Rats;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 1995., IEEE 17th Annual Conference

Conference_Location

Montreal, Que.

Print_ISBN

0-7803-2475-7

Type

conf

DOI

10.1109/IEMBS.1995.579815

Filename

579815