Feasibility of determining diffusion characteristics of bioceramics using gamma scintigraphy

Author

Smith, Jeanne A. ; Reynolds, David B. ; Bajpai, Praphulla K. ; Sedaghat, Alireza

Author_Institution

Dept. of Biomed. & Human Factors Eng., Wright State Univ., Dayton, OH, USA

fYear

1996

fDate

29-31 Mar 1996

Firstpage

231

Lastpage

234

Abstract

This study investigated the feasibility of determining an apparent diffusion coefficient for diffusion of technetium-99m-labeled albumin (MICROLITE^R) through ZCAP (Zinc-Calcium-Phosphorous Oxide) ceramics. Gamma scintigraphy was used for non-invasive observation of diffusion. Data analysis assumed a well-mixed solution, steady-state conditions over the measurement time interval, and passive diffusion as the primary mode of mass transport through the ceramic. Attenuation of 140 keV gamma rays was found to be significant in ZCAP ceramic. Although the data obtained was not adequate to calculate an apparent diffusion coefficient, such a determination appears feasible with modifications to the test protocol

Keywords

biodiffusion; biomedical equipment; ceramics; patient treatment; radioisotope imaging; 140 keV; MICROLITE; Tc; ZCAP ceramics; apparent diffusion coefficient; bioceramics; diffusion characteristics determination feasibility; gamma rays attenuation; gamma scintigraphy; mass transport; measurement time interval; passive diffusion; technetium-99m-labeled albumin; test protocol modifications; zinc-calcium-phosphorous oxide ceramics; Bioceramics; Biomedical engineering; Ceramics; Data analysis; Drugs; Human factors; In vivo; Testing; Time measurement; Volume measurement;

fLanguage

English

Publisher

ieee

Conference_Titel

Biomedical Engineering Conference, 1996., Proceedings of the 1996 Fifteenth Southern

Conference_Location

Dayton, OH

Print_ISBN

0-7803-3131-1

Type

conf

DOI

10.1109/SBEC.1996.493157

Filename

493157