Title :
Development of a finite element model of molecular diffusion in living brain from in vivo magnetic resonance
Author :
McQueen, P.G. ; Jin, A.J. ; Pierpaoli, C. ; Basser, P.J.
Author_Institution :
Nat. Inst. of Health, Bethesda, MD, USA
Abstract :
Magnetic resonance imaging techniques measure in vivo the diffusion tensor of water in tissues. With some physiologically reasonable assumptions, this data can be incorporated into a finite element model of diffusive transport of macromolecules within living tissue. Here the authors present the results of applying this approach to model the transport of sucrose in living cat brain. They show that white matter fibers strongly bias the transport due to their anisotropic diffusive properties
Keywords :
biodiffusion; biological NMR; brain models; finite element analysis; molecular biophysics; water; H2O; anisotropic diffusive properties; finite element model; in vivo magnetic resonance; living cat brain; macromolecules transport; molecular diffusion; physiologically reasonable assumptions; sucrose; water diffusion tensor; white matter fibers; Anisotropic magnetoresistance; Brain modeling; Coils; Diffusion tensor imaging; Finite element methods; Image resolution; In vivo; Magnetic resonance imaging; Sugar; Tensile stress;
Conference_Titel :
Biomedical Engineering Conference, 1996., Proceedings of the 1996 Fifteenth Southern
Conference_Location :
Dayton, OH
Print_ISBN :
0-7803-3131-1
DOI :
10.1109/SBEC.1996.493206
