Thermal stress in blood vessels during cryopreservation processes

Author

Gao, D.Y. ; Dankert, D.W. ; Pidaparti, R.M. ; Critser, J.K.

Author_Institution

Cryobiol. Res. Inst., Methodist Hospital of Indiana, Indianapolis, IN, USA

fYear

1996

fDate

29-31 Mar 1996

Firstpage

473

Lastpage

476

Abstract

A crucial problem in the cryopreservation of human blood vessels is fracture in the frozen tissue caused by thermal stress. A finite element model of human blood vessel was developed to investigate heat transfer and the thermal stress in blood vessels during the cooling process. Results from computer simulation indicates that the magnitude and distribution of the thermal stress in blood vessels are greatly affected by cooling rate and the nature of the constitutive law of the frozen biomaterial. A low cooling rate generates much lower thermal stress than a high cooling rate, and hence should be used in the cryopreservation

Keywords

biological techniques; biothermics; cooling; finite element analysis; freezing; low-temperature techniques; physiological models; computer simulation; constitutive law; cooling rate; cryopreservation processes; finite element model; frozen biomaterial; frozen tissue fracture; heat transfer; human blood vessels; thermal stress; Blood vessels; Cooling; Finite element methods; Heat transfer; Humans; Ice; Mechanical factors; Temperature; Thermal conductivity; Thermal stresses;

fLanguage

English

Publisher

ieee

Conference_Titel

Biomedical Engineering Conference, 1996., Proceedings of the 1996 Fifteenth Southern

Conference_Location

Dayton, OH

Print_ISBN

0-7803-3131-1

Type

conf

DOI

10.1109/SBEC.1996.493279

Filename

493279