Computational dissection of regulatory networks using diverse high-throughput data

Summary form only given. The maturation of high-throughput technologies and the availability of whole genome sequences make it possible to apply holistic computational approaches to the study of biological systems. The use of high-throughput technologies requires the development of advanced computational methods and tools that would enable the elicitation of significant biological knowledge from the vast amounts of data generated by these methods. Our group has been developing a battery of such methodologies and incorporated some of them in several tools such as CLICK, PRIMA, SAMBA, EXPANDER, SHARP, Binding Site Evolution and MetaReg.