DocumentCode :
3413925
Title :
Algorithmic research problems in molecular bioinformatics
Author :
Lengauer, Thomas
Author_Institution :
German Nat. Res. Center, for Comput. Sci., GMD, St.Augustin, Germany
fYear :
1993
fDate :
7-9 Jun 1993
Firstpage :
177
Lastpage :
192
Abstract :
The large amounts of data being assembled in the genome sequencing projects provide a grand challenge to science, namely their interpretation. There are several aspects to this interpretation such as identifying genes, determining the structure of the encoded proteins, discovering the mechanisms, by which proteins execute their biological function, and gaining insights into what role noncoding regions of the DNA play in gene regularization and expression, as well as metabolism. Due to the increased computing power and, especially, due to sophisticated graphics technology, one can visualize the structure and dynamics of molecules on the computer screen. What is still largely missing is a set of reliable models and algorithmic methods for deriving molecular structures on the basis of sequence data, as well as methods for the reliable prediction and analysis of interactions between biomolecules such as enzymes and their substrates. The author points out a few problems for which careful modeling and the development of appropriate algorithmic techniques is at the center of progress in computer-aided molecular biology
Keywords :
biology computing; computer graphics; macromolecules; molecular biophysics; molecular configurations; DNA; biological function; biomolecules; computer screen; computer-aided molecular biology; encoded proteins; enzymes; genome sequencing projects; graphics technology; molecular bioinformatics; molecular structures; molecules; noncoding regions; sequence data; Assembly; Biochemistry; Bioinformatics; Biological information theory; Biology computing; Computer graphics; DNA; Data visualization; Genomics; Proteins;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Theory and Computing Systems, 1993., Proceedings of the 2nd Israel Symposium on the
Conference_Location :
Natanya
Print_ISBN :
0-8186-3630-0
Type :
conf
DOI :
10.1109/ISTCS.1993.253471
Filename :
253471
Link To Document :
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