DocumentCode :
3422586
Title :
Exploring semantic memory areas by means of parametric models of f-MRI data
Author :
Baselli, G. ; Rizzo, G. ; Valsasina, P. ; Zanolin, D. ; Vitali, P. ; Tettamanti, M. ; Perani, D. ; Cerutti, S. ; Fazio, F.
Author_Institution :
Dept. of Biomed. Eng., Politecnico di Milano, Milan, Italy
fYear :
2003
fDate :
20-22 March 2003
Firstpage :
511
Lastpage :
514
Abstract :
In 10 right-handed volunteers, BOLD f-MRI activity was acquired during a protocol of mental speech production tasks. A task lasted 30 sec and consisted in recalling as many as possible animals (AN) or tools (TO). The protocol include 3 AN tasks and 3 TO tasks, each preceded by 30 sec rest (RE). By means of EPI the cerebral volume was acquired with a repetition time of 3 sec. After adjustment in stereotactic coordinates, spatial and temporal filtering, the time series of average activity in spherical regions with a 5 min radius were extracted relevant to Broca´s (BR) area, the left mesial (MFG) and lateral (LFG) fusiform gyrus. An interaction model, estimating a modulation index of the connection between either MGF or LFG with BR was able to detect an increased MFG/BR connectivity during TO and increased LFG/BR connectivity during AN; however, this model failed in a subject by subject analysis. On the contrary a simpler correlation model, which separately analyzed the two tasks, was able to detect consistent changes in 7/10 MSG areas and in 9/10 LFG areas. We conclude that with an appropriate data analysis model the application of functional imaging can be widened from pure physiological studies to the clinical analysis in lesions or pathologies involving semantic memory and speech areas.
Keywords :
biomedical MRI; brain; speech; BOLD f-MR1 activity; MFG/BR connectivity; cerebral volume; clinical analysis; correlation model; data analysis model; f-MRI data; functional imaging; fusiform gyrus; mental speech production tasks; modulation index; parametric models; right-handed volunteers; semantic memory areas; spatial filtering; stereotactic coordinates; temporal filtering; time series; Animals; Clinical diagnosis; Data analysis; Failure analysis; Filtering; Lesions; Modulation; Parametric statistics; Protocols; Speech;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Neural Engineering, 2003. Conference Proceedings. First International IEEE EMBS Conference on
Print_ISBN :
0-7803-7579-3
Type :
conf
DOI :
10.1109/CNE.2003.1196875
Filename :
1196875
Link To Document :
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