Microfluidic detection and analysis by integration of evanescent wave sensing with thermocapillary actuation

Author

Valentino, J.P. ; Troian, S.M. ; Wagner, S.

Author_Institution

Dept. of Electr. Eng., Princeton Univ., NJ, USA

fYear

2005

fDate

30 Jan.-3 Feb. 2005

Firstpage

730

Lastpage

733

Abstract

An integrated system capable of microfluidic actuation, detection and sensing is described which combines evanescent wave sensing with thermocapillary manipulation. Liquid droplets or streams transported across the beam path of a planar thin film waveguide, which encapsulates the microheater array, induce attenuation of the propagating waveguide modes. The attenuated signal is used to monitor droplet location, dye concentration in aqueous solutions and reaction kinetics for enzymatic hydrolysis of the sugar X-galactose by beta-galactosidase.

Keywords

biological techniques; biosensors; drops; fibre optic sensors; microactuators; microfluidics; micromanipulators; optical waveguides; beam path; beta-galactosidase; droplet location; dye concentration; enzymatic hydrolysis; evanescent wave sensing; liquid droplets; microfluidic actuation; microfluidic analysis; microfluidic detection; microheater array; planar thin film waveguide; reaction kinetics; sugar X-galactose; thermocapillary actuation; thermocapillary manipulation; Microfluidics; Optical films; Optical mixing; Optical planar waveguides; Optical refraction; Optical sensors; Optical surface waves; Optical variables control; Optical waveguides; Planar waveguides;

fLanguage

English

Publisher

ieee

Conference_Titel

Micro Electro Mechanical Systems, 2005. MEMS 2005. 18th IEEE International Conference on

ISSN

1084-6999

Print_ISBN

0-7803-8732-5

Type

conf

DOI

10.1109/MEMSYS.2005.1454033

Filename

1454033