Experimental study on the mechanism of raspberry ketone on simple obesity and insulin resistance relevant to obesity

The Purpose of this research is to discuss the function mechanism of raspberry ketone on simple obesity and the influence of resistance on obesity relevant insulin. There were 40 SD rats of SPF grade, and the male to female ratio was 1:1. They were randomly divided into 5 groups: NC fed with normal diet. MC fed with high-fat diet. RKL, RKM, and RKH groups fed with high-fat diet and were administered intragastrically with 0.5%, 1%, and 2% of RK for 4 weeks. After 8 weeks, some parameters were tested. The results were processed by statistical analysis. Compared with NC, TG, TC, LDL-C, GLU, INS, IRI, FFA, LEP, TNF-α of MC were significantly increased. Therefore, HDL-C, ISI and APN were significantly decreased. Compared with MC, each parameter in RKL, RKM, and RKH was significantly improved. The results showed that RK have anti-obesity function through combined effects of improving insulin resistance.