Evaluation of a Propofol and Remifentanil interaction model for predictive control of anesthesia induction

Author

Ionescu, Clara M. ; De Keyser, Robin ; Struys, Michel M R F

Author_Institution

Dept. of Electr. Energy, Syst. & Autom., Ghent Univ., Ghent, Belgium

fYear

2011

fDate

12-15 Dec. 2011

Firstpage

7374

Lastpage

7379

Abstract

This paper introduces a simplified linear interaction model between two drugs, namely Propofol and Remifentanil, which will be used in a model based predictive control algorithm for (nonlinear) automatic induction and regulation of DOA. Depth of anesthesia (DOA) is evaluated by means of the Bispectral index (BIS). The simulation tests are performed on a set of 24 virtually generated realistic patient models. The results are promising and the performance of the controller shows a high-efficiency, optimal dosage of the two drugs in order to achieve the desired BIS reference.

Keywords

drugs; predictive control; BIS reference; DOA; Propofol; Remifentanil interaction model; anesthesia induction; bispectral index; depth of anesthesia; drug optimal dosage; linear interaction model; model based predictive control algorithm; Anesthesia; Brain modeling; Delay effects; Drugs; Electroencephalography; Mathematical model; Predictive models;

fLanguage

English

Publisher

ieee

Conference_Titel

Decision and Control and European Control Conference (CDC-ECC), 2011 50th IEEE Conference on

Conference_Location

Orlando, FL

ISSN

0743-1546

Print_ISBN

978-1-61284-800-6

Electronic_ISBN

0743-1546

Type

conf

DOI

10.1109/CDC.2011.6160404

Filename

6160404