DocumentCode :
3425932
Title :
Pharmacokinetics and tissue distribution study of schisandrin in mice by liquid chromatography
Author :
Zhang Xiurong ; Guan Jiao ; Zhu Heyun ; Zhao Yang ; Sun Deyi
Author_Institution :
Coll. of Pharmacy, Jilin Med. Coll., Jilin, China
fYear :
2011
fDate :
19-22 Aug. 2011
Firstpage :
272
Lastpage :
275
Abstract :
A HPLC method was developed to determine the concentration of schisandrin in plasma and tissues of mouse. The separation was obtained on a C18 column with a mobile phase of methanol: water (58:42, v/v), UV detector was monitored at 250 nm. The established method was successfully used to the research of pharmacokinetics and tissue distribution of schisandrin after intragastric administration of a 15 mg/kg dose to mice. The results of pharmacokinetic study indicate that schisandrin is quickly absorbed and eliminated. Tissue distribution research shows that liver is the major distribution tissue of schisandrin, which is beneficial to the treatment of hepatic disease.
Keywords :
biological tissues; chromatography; diseases; drugs; liver; C18 column; HPLC method; UV detector; hepatic disease; intragastric administration; liquid chromatography; liver; methanol; mice; mobile phase; pharmacokinetics; plasma; schisandrin; tissue distribution study; water; wavelength 250 nm; Accuracy; Calibration; Detectors; Liver; Methanol; Mice; Plasmas; HPLC; pharmacokinetics; plasma; schisandrin; tissue distribution;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Human Health and Biomedical Engineering (HHBE), 2011 International Conference on
Conference_Location :
Jilin
Print_ISBN :
978-1-61284-723-8
Type :
conf
DOI :
10.1109/HHBE.2011.6027951
Filename :
6027951
Link To Document :
بازگشت