Metabolic system identification using simulation and fast Fourier transformation

Author

Daloze, Thierry ; Fink, Guy ; Brunengraber, H. ; Corinthios, M.J.

Author_Institution

Ecole Polytech. de Montreal, Que., Canada

fYear

1988

fDate

4-7 Nov. 1988

Firstpage

503

Abstract

A biological model of ketone body metabolism in the rat heart highlights pseudoketogenesis caused by reversible activation of acetoacetate. A mathematical system based on differential equations of isotopic fluxes is solved numerically. Different sets of unknown kinetic constants cannot be discriminated because of concentration patterns, but these patterns can be further analyzed. System poles are located by a fast Z-transform algorithm. The Z plane is scanned along constant damping contours, using an efficient fast Fourier transform algorithm. This simulation and Z-domain scanning approach reduce the need for subjective analysis of experimental data.<>

Keywords

fast Fourier transforms; identification; physiological models; biological model; concentration patterns; constant damping contours; differential equations; fast Fourier transformation; fast Z-transform algorithm; isotopic fluxes; ketone body metabolism; kinetic constants; mathematical system; metabolic system identification; pseudoketogenesis; rat heart; simulation; system poles;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 1988. Proceedings of the Annual International Conference of the IEEE

Conference_Location

New Orleans, LA, USA

Print_ISBN

0-7803-0785-2

Type

conf

DOI

10.1109/IEMBS.1988.94630

Filename

94630