A survey of recent work on evolutionary approaches to the protein folding problem

Author

Greenwood, Garrison W. ; Shin, Jae-Min ; Lee, Byungkook ; Fogel, Gary B.

Author_Institution

Dept. of Comput. Sci., Western Michigan Univ., Kalamazoo, MI, USA

Volume

1

fYear

1999

fDate

1999

Abstract

A problem of immense importance in computational biology is the determination of the functional conformations of protein molecules. With the advent of faster computers, it is now possible to use rules to search conformation space for protein structures that have minimal free energy. The paper surveys work done in the last five years (1994-99) using evolutionary search algorithms to find low energy protein conformations. In particular, a detailed description is included of some work recently started at the National Cancer Institute, which uses evolution strategies

Keywords

biology computing; evolutionary computation; molecular biophysics; proteins; search problems; computational biology; conformation space; evolution strategies; evolutionary approaches; evolutionary search algorithms; functional conformations; low energy protein conformations; minimal free energy; protein folding problem; protein molecules; protein structures; Amino acids; Biological systems; Cancer; Computational biology; Evolution (biology); Evolutionary computation; Laboratories; Proteins; Sequences; Shape;

fLanguage

English

Publisher

ieee

Conference_Titel

Evolutionary Computation, 1999. CEC 99. Proceedings of the 1999 Congress on

Conference_Location

Washington, DC

Print_ISBN

0-7803-5536-9

Type

conf

DOI

10.1109/CEC.1999.781969

Filename

781969