Effects of Arthrigia on adjuvant arthritis rats´ serum TNF-α

Author

Xi Chen ; Fan Li

Author_Institution

Dept. of Pathogenibiology, Jilin Univ., Changchun, China

fYear

2011

fDate

19-22 Aug. 2011

Firstpage

438

Lastpage

441

Abstract

Rheumatoid Arthritis (RA) is a systemic chronic autoimmune disease. To study the therapeutic mechanism of effects of Skullcap Brightviolet (SB), glucosamine/chondroitin (GC), and the combination of them (named Arthrigia) on RA. With the adjuvant arthritis (AA) rat models, we observed the protective effects of oral SB, GC and Arthrigia in different concentrations on AA in rats. We further examined the immunological mechanism of the combination of them by testing the rats´ secretion of TNF-α. The results showed that Arthrigia inhibited the production and secretion of TNF-α factors in some extent, and its effects are more potent the single SB or GC. The present study provides the experimental evidences for Arthrigia for its further development, clinical prevention and treatment of RA.

Keywords

biomedical materials; diseases; medical disorders; organic compounds; patient treatment; GC; adjuvant arthritis rat model; adjuvant arthritis rat serum TNF-α; arthrigia; glucosamine-chondroitin; immunological mechanism; oral SB; protective effects; rat secretion; rheumatoid arthritis; skullcap brightviolet; systemic chronic autoimmune disease; therapeutic mechanism; Arthritis; Drugs; Educational institutions; Humans; Immune system; Joints; Rats; Arthrigia; Rheumatoid Arthritis (RA); Skullcap Brightviolet (SB); TNF-α; glucosamine/chondroitin (GC);

fLanguage

English

Publisher

ieee

Conference_Titel

Human Health and Biomedical Engineering (HHBE), 2011 International Conference on

Conference_Location

Jilin

Print_ISBN

978-1-61284-723-8

Type

conf

DOI

10.1109/HHBE.2011.6027993

Filename

6027993