Title :
Effects of Arthrigia on adjuvant arthritis rats´ serum TNF-α
Author :
Xi Chen ; Fan Li
Author_Institution :
Dept. of Pathogenibiology, Jilin Univ., Changchun, China
Abstract :
Rheumatoid Arthritis (RA) is a systemic chronic autoimmune disease. To study the therapeutic mechanism of effects of Skullcap Brightviolet (SB), glucosamine/chondroitin (GC), and the combination of them (named Arthrigia) on RA. With the adjuvant arthritis (AA) rat models, we observed the protective effects of oral SB, GC and Arthrigia in different concentrations on AA in rats. We further examined the immunological mechanism of the combination of them by testing the rats´ secretion of TNF-α. The results showed that Arthrigia inhibited the production and secretion of TNF-α factors in some extent, and its effects are more potent the single SB or GC. The present study provides the experimental evidences for Arthrigia for its further development, clinical prevention and treatment of RA.
Keywords :
biomedical materials; diseases; medical disorders; organic compounds; patient treatment; GC; adjuvant arthritis rat model; adjuvant arthritis rat serum TNF-α; arthrigia; glucosamine-chondroitin; immunological mechanism; oral SB; protective effects; rat secretion; rheumatoid arthritis; skullcap brightviolet; systemic chronic autoimmune disease; therapeutic mechanism; Arthritis; Drugs; Educational institutions; Humans; Immune system; Joints; Rats; Arthrigia; Rheumatoid Arthritis (RA); Skullcap Brightviolet (SB); TNF-α; glucosamine/chondroitin (GC);
Conference_Titel :
Human Health and Biomedical Engineering (HHBE), 2011 International Conference on
Conference_Location :
Jilin
Print_ISBN :
978-1-61284-723-8
DOI :
10.1109/HHBE.2011.6027993
