Title :
Effect of resveratrol on oxidative stress in kidneys of diabetic rats
Author :
Zhu Lu-jia ; Zhang Li-jing
Author_Institution :
Coll. of Quality & Tech. Supervision, Hebei Univ., Baoding, China
Abstract :
Objective: Observation the effect of resveratrol on oxidative stress in kidneys of diabetic rats. Methods: Fifty Sprague Dawley(SD) rats (male) were randomly divided into four groups: the normal rats, the diabetic rats treated with resveratrol(10mg/kg/d), the diabetic rats treated with resveratrol(20mg/kg/d) and the diabetic rats treated with resveratrol(40mg/kg/d). After 12 weeks, the levels of blood glucose, serum creatinine, 24h urinary protein, the contents of malondialdehyde(MDA), glutathione(GSH) and the activity of antioxidant enzymes total superoxide dismutase (T-SOD) in the renal tissue were measured. Results: Compared with the diabetic model group, the levels of blood glucose, serum creatinine, 24h urinary protein and MDA in the renal tissue were decreased, the activity of T-SOD and GSH in the renal tissue was increased, the renal pathologic changes was improved in resveratrol treated group. Conclusions: Resveratrol can increase the renal function and antioxidant capacity, it has protective effect on kidney of diabetic rats.
Keywords :
biochemistry; biological tissues; blood; diseases; enzymes; kidney; molecular biophysics; oxidation; GSH; MDA; Sprague Dawley rats; T-SOD; antioxidant capacity; antioxidant enzymes; blood glucose; diabetic rats; glutathione; kidneys; malondialdehyde; oxidative stress; renal function; renal pathologic changes; renal tissue; resveratrol treated group; serum creatinine; superoxide dismutase; time 24 h; urinary protein; Blood; Delta modulation; Diabetes; Kidney; Proteins; Rats; Stress; diabetes mellitus; diabetic nephropathy; oxidative stress; rat; resveratrol;
Conference_Titel :
Human Health and Biomedical Engineering (HHBE), 2011 International Conference on
Conference_Location :
Jilin
Print_ISBN :
978-1-61284-723-8
DOI :
10.1109/HHBE.2011.6028040
