DocumentCode
3429897
Title
A mathematical model of tissue oxygen pressure time dynamics
Author
Di Giammarco, Patrizia ; Ursino, Mauro ; Belardinelli, Enzo
Author_Institution
Dept. of Electron. Inf. & Syst. Sci., Bologna Univ., Italy
fYear
1988
fDate
4-7 Nov. 1988
Firstpage
548
Abstract
An original mathematical model of gaseous exchange from capillaries to tissue is presented. Equations for the model have been derived by applying the mass preservation principle to capillary blood and tissue and by making use of Fick´s law. The model has been used to simulate the time pattern of mean tissue oxygen pressure in response to a step alteration in blood flow for two different tissues: the rat´s cerebral gray matter and the sciatic nerve. Simulation allows dependence of tissue oxygen dynamics on the main physical and geometrical model parameters (like intercapillary distance and oxygen consumption rate) to be analyzed.<>
Keywords
biotransport; physiological models; Fick´s law; capillary blood; cerebral gray matter; gaseous exchange; intercapillary distance; mass preservation principle; mathematical model; rat; sciatic nerve; tissue O/sub 2/ pressure time dynamics;
fLanguage
English
Publisher
ieee
Conference_Titel
Engineering in Medicine and Biology Society, 1988. Proceedings of the Annual International Conference of the IEEE
Conference_Location
New Orleans, LA, USA
Print_ISBN
0-7803-0785-2
Type
conf
DOI
10.1109/IEMBS.1988.94658
Filename
94658
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