The effect of HLA-DRB1 alleles in immune response to hepatitis B vaccine

To research into the significance of HLA-DRB1 alleles in the immune response to hepatitis B vaccine, HLA-DRB1 alleles of 84 cases with Hepatitis B vaccine non or hypo-responses were detected with polymerase chain reaction sequence-specific primer(PCR-SSP), and were compared with 78 cases with medium or hyper-responses. According to the research, the allelic frequencies of HLA-DRB1*12, 14, 15 in non or hypo-responders group is 4.76%, 23.8% and 7.14% respectively, and in medium or hyper-responders group 23.1%, 5.13% and 24.4%, which shows significant differences between the two groups (P<; 0.05); while the allelic frequencies of HLA-DRB1*07, 09, 11, 13 show no significant differences between the two groups(P >; 0.05). Thus, there may exist certain relevance between different allelic frequencies of HLA-DRB1 and hepatitis B vaccine immune response. Therefore, the analysis of allelic frequencies of HLA-DRB1 will have great effect on the hepatitis B vaccine immune response system.