DocumentCode :
3429970
Title :
Effect of 17 β-estradiol on Ca2+ channel in mouse C2C12 myoblasts
Author :
Bing Leng ; Hao-Gang Xue
Author_Institution :
Dept. of Orthopedic Surg., Affiliated Hosp. of Beihua Univ., Jilin, China
fYear :
2011
fDate :
19-22 Aug. 2011
Firstpage :
569
Lastpage :
571
Abstract :
The present study has investigated effect of 17β-estradiol on Ca2+ channel in mouse C2C12 myoblasts. Whole cell Patch-clamp analysis was used to observe the effects of different doses of 17β-estradiol on changes of Ca2+ channel in C2C12 myoblasts. Currents of Ca2+ were recorded in 67% C2C12 myoblasts. Groups of 30 mol · L-1 and 20 mol L-1 increased currents of Ca2+ significiantly (P<;0.05). While group of 10 mol · L-1 did not change. The present results revealed that 17β-estradiol may regulate C2C12 myoblasts by opening Ca2+ channel in myoblast cell line C2C12.
Keywords :
biological techniques; calcium; cellular biophysics; organic compounds; 17β-estradiol effect; Ca2+channel; mouse C2C12 myoblasts; myoblast cell line C2C12; whole cell patch-clamp analysis; Bones; Calcium; Clamps; Humans; Mice; Muscles; Osteoporosis; 17β-estraawl; C2C12 myoblasts; Ca2+ channel;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Human Health and Biomedical Engineering (HHBE), 2011 International Conference on
Conference_Location :
Jilin
Print_ISBN :
978-1-61284-723-8
Type :
conf
DOI :
10.1109/HHBE.2011.6028375
Filename :
6028375
Link To Document :
https://search.ricest.ac.ir/dl/search/defaultta.aspx?DTC=49&DC=3429970
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