Protective effects of puerarin solution on alcohol encephalopathy hippocampus

Author

Wen-bo Ju ; Zhi-wei Qu ; Wei-gao Shen

Author_Institution

Beihua Univ., Jilin, China

fYear

2011

fDate

19-22 Aug. 2011

Firstpage

606

Lastpage

608

Abstract

To examine the effects of Puerarin solution on alcohol-induced injuries in hippocampus. Thirty Wistar rats were divided into control group, model group and puerarin group. After 30 days, the Endotoxin (ET) levels in plasma and TNF-α in cerebral tissue were measured. Pathological changes in cerebral tissue were observed by light microscope. ET and TNF-α in the model group were significantly higher than those in the control group (p<;0.05); ET and TNF-α in puerarin group was slightly higher than those in the control group and significantly lower than those in the model group (p<;0.01); Mild pathological changes in hippocampus of model group, no obvious pathological changes in the other groups. The protective effects of puerarin may be related to its inhibition of ET and TNF-α production.

Keywords

biological tissues; biomedical materials; brain; cellular biophysics; diseases; injuries; neurophysiology; optical microscopy; organic compounds; TNF-α production; alcohol encephalopathy hippocampus; alcohol-induced injuries; cerebral tissue; endotoxin levels; light microscopy; mild pathological changes; protective effects; puerarin solution; Blood; Brain modeling; Hippocampus; Liver; Plasmas; Rats; Alcohol; Puerarin; encephalopathy; hippocampus; plasma endotoxin (ET);

fLanguage

English

Publisher

ieee

Conference_Titel

Human Health and Biomedical Engineering (HHBE), 2011 International Conference on

Conference_Location

Jilin

Print_ISBN

978-1-61284-723-8

Type

conf

DOI

10.1109/HHBE.2011.6028385

Filename

6028385