Effects of Geraniin in Geranium sibiricum L. on antioxidant function of S180 mice

Objective: to investigate effects of Geraniin in Geranium sibiricum L. on antioxidant function of S₁₈₀ mice. Methods: S₁₈₀ entity-tumor mice as study model were used to investigate effects of Geraniin on tumor inhibition rate and indices of immune organs of S₁₈₀ mice; kits were used to determine SOD activity and T-AOC activity in red blood cells and MDA content of red blood cells in the whole blood of S₁₈₀ mice. Results: Geraniin could significantly inhibit growth of S₁₈₀ entity-tumor, significantly increase thymus index and spleen index, significantly increase SOD activity and T-AOC activity in red blood cells of S₁₈₀ mice and significantly reduce MDA content of red blood cells in the whole blood of S₁₈₀ mice. Conclusion: Geraniin could significantly inhibit the growth of entity-tumors of S₁₈₀ mice and its effect mechanism was possibly associated with increase of antioxidant function of S₁₈₀ entity-tumor mice.