Title :
Matching an oscillator model to a phase response curve
Author :
Sacré, Pierre ; Sepulchre, Rodolphe
Author_Institution :
Dept. of Electr. Eng. & Comput. Sci. (B28), Univ. of Liege, Liege, Belgium
Abstract :
The Phase Response Curve (PRC) has proven a useful tool for the reduction of complex oscillator models. It is also an information often experimentally available to the biologist. This paper introduces a numerical tool based on the sensitivity analysis of the PRC to adapt initial model parameters in order to match a particular PRC shape. We illustrate the approach on a simple biochemical model of circadian oscillator.
Keywords :
biology; oscillators; PRC; biochemical model; circadian oscillator; complex oscillator models; initial model parameters; numerical tool; phase response curve; sensitivity analysis; Adaptation models; Biological system modeling; Orbits; Oscillators; Sensitivity analysis; Space vehicles;
Conference_Titel :
Decision and Control and European Control Conference (CDC-ECC), 2011 50th IEEE Conference on
Conference_Location :
Orlando, FL
Print_ISBN :
978-1-61284-800-6
Electronic_ISBN :
0743-1546
DOI :
10.1109/CDC.2011.6161168
