Title :
Study of Rats´ Mammary Precancer models-induced by DMBA combined estrogen and progesterone
Author :
Min Ma ; Dehui Li ; Guijuan Zhang ; Rui Liao ; Bizhu Tan
Author_Institution :
Dept. of Traditional Chinese Med., Jinan Univ., Guangzhou, China
Abstract :
Objective: To explore using 7, 12-Dimethylbenz[a] anthracen(DMBA) combined estrogen and progesterone induce Rats Model of Mammary Precancer, and investigate the inhibitory effect of tamoxifen ointment. Methods: 30 virginal female SD rats were randomly allocated into three groups, A: Blank control group (10); B: DMBA+hormones group (10); C: TAM group (10). The general morphology and pathology were observed when the rats were executed after 60 days. Results: The incidence of premalignant breast disease in model group B was 87.5%, while group C was 47.5%. Group B was significantly higher than group C (P<;0.01). Conclusion: DMBA+hormones method is a method to establish Rats Model of Mammary Precancer. Tamoxifen could effectively prevent the occurrence of DMBA+hormones induced breast precancer in rats.
Keywords :
biological tissues; biomedical measurement; cancer; drugs; organic compounds; 7,12-dimethylbenzanthracen; DMBA induced mammary precancer; estrogen; premalignant breast disease; progesterone; rat mammary precancer models; tamoxifen ointment; Breast tumors; Cancer; Lesions; Rats; DMBA; animal model; estrogen; mammary precancerous lesion; pathology; progesterone; tamoxifen;
Conference_Titel :
Human Health and Biomedical Engineering (HHBE), 2011 International Conference on
Conference_Location :
Jilin
Print_ISBN :
978-1-61284-723-8
DOI :
10.1109/HHBE.2011.6029068
