DocumentCode :
3440889
Title :
Pemetrexed versus docetaxel single agent chemotherapy in chemotherapy-naive elderly patients with advanced non-small cell lung cancer
Author :
Xin Hua ; Han Zhenguo ; Huang Haibo
Author_Institution :
Dept. of Thoracic Surg., Jilin Univ., Changchun, China
fYear :
2011
fDate :
19-22 Aug. 2011
Firstpage :
1331
Lastpage :
1334
Abstract :
To compare the efficacy and toxicity of pemetrexed and docetaxel single agent chemotherapy in chemotherapy-naive elderly patients with advanced non-small cell lung cancer, the clinical data of 54 elderly patients were retrospectively analyzed. 19 patients accepted pemetrexed single agent chemotherapy and 35 patients accepted docetaxel single agent chemotherapy. The median OS of pemetrexed group and docetaxel group was 16.10 months and 18.90 months respectively. In the pemetrexed group, DCR was 73.68%. In the docetaxel group, DCR was 71.43%. No statistically significant difference was found. The toxicity of pemetrexed single agent chemotherapy was lower in terms of hematologic and alopecia. In the subgroup analysis, the OS and DCR of non-squamous non-small cell lung cancer in pemetrexed group were longer and higher than those of the docetaxel group. Elderly patients with good Performance Status and good body condition can tolerate the pemetrexed and docetaxel single agent chemotherapy. The pemetrexed single agent chemotherapy was recommended for lower toxicity, especially in non-squamous patients.
Keywords :
biomedical measurement; cancer; drugs; geriatrics; lung; statistical analysis; toxicology; tumours; advanced nonsmall cell lung cancer; alopecia; chemotherapy naive elderly patients; docetaxel; drug efficacy; drug toxicity; hematology; nonsquamous nonsmall cell lung cancer; pemetrexed; single agent chemotherapy; Cancer; Diseases; Drugs; Guidelines; Hospitals; Lungs; Senior citizens; carcinoma; chemotherapy; docetaxel; elderly; non-small-cell lung cancer; pemetrexed;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Human Health and Biomedical Engineering (HHBE), 2011 International Conference on
Conference_Location :
Jilin
Print_ISBN :
978-1-61284-723-8
Type :
conf
DOI :
10.1109/HHBE.2011.6029079
Filename :
6029079
Link To Document :
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