DocumentCode :
3445525
Title :
Numerical evaluation of myoglobin facilitated oxygen diffusion in the heart
Author :
Gardner, Jason D. ; Schubert, Roy W.
Author_Institution :
Dept. of Biomed. Eng., Louisiana Tech. Univ., Ruston, LA, USA
fYear :
1997
fDate :
4-6 Apr 1997
Firstpage :
366
Lastpage :
369
Abstract :
Myoglobin facilitated oxygen diffusion and Michaelis-Menten kinetics are added to an experimentally-validated oxygen transport to cardiac tissue model to determine the steady-state function of myoglobin in working heart tissue. Previous modeling of tissue oxygen partial pressure (pO2) data suggests that the oxygen diffusion coefficient in working heart tissue is greater than expected. To fit the pO2 data, the tissue oxygen diffusion coefficient in the model must be elevated to 8 to 12 times reported values. These elevated values of the tissue oxygen diffusion coefficient are not acceptable based upon current understanding of cardiac muscle physiology. In this paper the effect of including myoglobin facilitated diffusion in the model is evaluated to determine if this phenomenon can explain the need for an elevated oxygen diffusion coefficient. The radially-averaged, axially-distributed (RAAD) model considers axial diffusion of oxygen in tissue, myoglobin facilitation of oxygen transport, and pO2-dependent oxygen consumption. Models are solved numerically using a variable-mesh finite-difference scheme. Parameters are optimized with Nelder-Mead simplexing and are chosen to minimize the sum-of-squares error between model pO2 predictions and pO2 data. The addition of myoglobin to the RAAD model does not provide a better data fit. Simulations lead to the conclusion that myoglobin facilitation is not responsible for the elevated oxygen diffusion found through modeling pO2 data. Also, simulations indicate that myoglobin does not act to facilitated diffusive transport of oxygen in the steady-state isolated perfused cat heart preparation. A possible explanation for the elevated oxygen diffusion coefficient is tissue stirring by contractile elements
Keywords :
biodiffusion; biomembrane transport; cardiology; finite difference methods; muscle; oxygen; physiological models; proteins; Michaelis-Menten kinetics; Nelder-Mead simplexing; O2; cardiac muscle physiology; cardiac tissue model; contractile elements; elevated oxygen diffusion coefficient; heart; myoglobin facilitated oxygen diffusion; numerical evaluation; oxygen transport; pO2-dependent oxygen consumption; radially-averaged axially-distributed model; steady-state function; steady-state isolated perfused cat heart preparation; sum-of-squares error; tissue stirring; variable-mesh finite-difference scheme; Biomedical engineering; Cardiac tissue; Heart; Histograms; Kinetic theory; Muscles; Oxygen; Physiology; Predictive models; Steady-state;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Biomedical Engineering Conference, 1997., Proceedings of the 1997 Sixteenth Southern
Conference_Location :
Biloxi, MS
ISSN :
1086-4105
Print_ISBN :
0-7803-3869-3
Type :
conf
DOI :
10.1109/SBEC.1997.583312
Filename :
583312
Link To Document :
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