Title :
Understanding centrality-lethality rule in yeast Protein-Protein Interaction network by topological property
Author :
Dong Yun-Yuan ; Wang Zheng-Hua ; Liu Qi-Jun ; Yong-xian, Wang
Author_Institution :
Sch. of Comput., Nat. Univ. of Defense Technol., Changsha, China
Abstract :
One of the most important problems in biology is to discover the relationship between topological properties and functional features of proteins in Protein-Protein Interaction (PPI) network. The centrality-lethality rule reveals that hub proteins tend to be more essential than non-hub proteins. Why hub proteins tend to be more essential? Here, we classified hub proteins into two types: essential hub and nonessential hub. We found that essential hubs are more important to the survival of the cell and they can be called intra-modular hubs while nonessential hubs tend to be inter-modular hubs.
Keywords :
biology computing; cellular biophysics; microorganisms; molecular biophysics; molecular configurations; pattern classification; proteins; biology; centrality-lethality rule; database; hub protein classification; inter-modular hub; intra-modular hub; nonessential hub protein; nonhub protein; protein functional feature; topological property; yeast protein-protein interaction network; Bioinformatics; Color; Correlation; Educational institutions; Genomics; Proteins; centrality; essential hub; nonessential hub; protein-protein interaction network;
Conference_Titel :
Information Technology and Artificial Intelligence Conference (ITAIC), 2011 6th IEEE Joint International
Conference_Location :
Chongqing
Print_ISBN :
978-1-4244-8622-9
DOI :
10.1109/ITAIC.2011.6030289
