Title :
Nanoshell-polymer composites for photothermally modulated drug delivery
Author :
Sershen, S.R. ; West, J.L. ; Westcott, S.L. ; Halas, N.J.
Author_Institution :
Dept. of Bioeng., Rice Univ., Houston, TX, USA
Abstract :
Summary form only given. Optically active gold nanoshells; have been incorporated into thermally, responsive copolymers of N-Isopropylacrylamide (NIPAAm) and acryl-amide (AAm) for the purpose of photothermally modulated drug delivery. The copolymer exhibits a lower critical solution temperature (LCST) that is slightly above body, temperature. When the temperature of the hydrogel exceeds its LCST, a rapid collapse occurs, expelling any material contained within the hydrogel. The gold nanoshells initiate a temperature increase, via targeted absorption of near IR light.
Keywords :
biomedical materials; composite materials; drug delivery systems; gels; gold; laser applications in medicine; nanostructured materials; photothermal effects; polymer blends; Au; Au nanoshells; N-isopropylacrylamide; acrylamide; body temperature; copolymer; critical solution temperature; hydrogel; nanoshell-polymer composites; near IR light; optically active Au nanoshells; photothermally modulated drug delivery; rapid collapse; targeted absorption; temperature increase; thermally responsive copolymers; Active appearance model; Drug delivery; Gaussian processes; Gold; Laser ablation; Nanobioscience; Optical control; Optical pulses; Optimized production technology; Temperature;
Conference_Titel :
Lasers and Electro-Optics, 2001. CLEO '01. Technical Digest. Summaries of papers presented at the Conference on
Conference_Location :
Baltimore, MD, USA
Print_ISBN :
1-55752-662-1
DOI :
10.1109/CLEO.2001.947975
