A microfluidic system with volume sensor and dielectric glucose sensor for continuous glucose monitoring

Author

Li, Di-Jie ; Yu, Haoyong ; Huang, Xumin ; Song, Bo ; Jia, Yunde ; Ji, Yuefeng ; Li, Ning ; Chen, Jiann-Jong ; Xu, Ke ; Lin, Qingli

Author_Institution

Tianjin Univ., Tianjin, China

fYear

2013

fDate

16-20 June 2013

Firstpage

365

Lastpage

368

Abstract

We present a microfluidic system for interstitial fluid (ISF) transdermal extraction, ISF volume measurement, and dielectric glucose sensing towards the application of continuous glucose monitoring. This device significantly incorporates a MEMS volume sensor, which measures extracted ISF volume via conductance monitoring, and integrates a MEMS dielectric glucose sensor, which specifically measures glucose concentrations in the transdermally extracted ISF via affinity binding. The volume sensor and the glucose sensor in the microfluidic system are characterized. The feasibility of the single-chip device for automated, accurate, and continuous monitoring of subcutaneous ISF glucose concentrations is verified.

Keywords

bioMEMS; chemical sensors; microfluidics; patient monitoring; sugar; ISF transdermal extraction; ISF volume measurement; MEMS volume sensor; affinity binding; continuous glucose monitoring; dielectric glucose sensing; dielectric glucose sensor; interstitial fluid transdermal extraction; microfluidic system; Dielectric measurement; Dielectrics; Electrodes; Microfluidics; Monitoring; Sugar; Volume measurement; Continuous glucose monitoring; Dielectric glucose sensor; Interstitial fluid transdermal extraction; Microfluidics; Volume sensor;

fLanguage

English

Publisher

ieee

Conference_Titel

Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS & EUROSENSORS XXVII), 2013 Transducers & Eurosensors XXVII: The 17th International Conference on

Conference_Location

Barcelona

Type

conf

DOI

10.1109/Transducers.2013.6626778

Filename

6626778