DocumentCode :
3458886
Title :
Local backscatter ultrasonic attenuation measurements in vitro (30 to 50 MHz) of the constituents of atherosclerotic plaques
Author :
Bridal, S.L. ; Fornès, P. ; Berger, G.
Author_Institution :
Lab. d´´Imagerie Parametrique, CNRS, Paris, France
Volume :
2
fYear :
1996
fDate :
3-6 Nov 1996
Firstpage :
1069
Abstract :
Identification of the constituents of atherosclerotic plaques (lipids, extracellular matrix, calcifications) using backscattered ultrasound could provide a means for the objective characterization of lesions that could eventually be applied in vivo. Towards this goal, backscattered rf from 33 excised segments of human aorta were acquired using a 50 MHz center frequency acoustic backscatter microscope. Within selected regions of interest (ROI) of the plaque and the media of each scanned segment, the ultrasonic attenuation (30 to 50 MHz) was estimated using a multinarrow-band technique. The composition of each ROI was assessed by histology. Fourteen ROIs were studied from each of the following tissue groups: normal media in regions free of plaque, normal media beneath atherosclerotic plaque, dense collagen, and lipids. The attenuation measured in lipidic regions was higher than that measured in either dense collagen or normal media. The slope of attenuation was also elevated in the lipidic regions of the plaque. These preliminary results demonstrate that ultrasonic attenuation offers promise as a parameter for the characterization of the composition and structure of atherosclerotic plaques which could eventually be applied in vivo
Keywords :
acoustic microscopy; backscatter; biomedical measurement; biomedical ultrasonics; cellular biophysics; ultrasonic scattering; 30 to 50 MHz; acoustic backscatter microscope; atherosclerotic plaque constituents; backscattered rf; backscattered ultrasound; calcifications; dense collagen; extracellular matrix; histology; human aorta; in vitro; lesions; lipids; local backscatter ultrasonic attenuation measurements; multinarrow-band technique; normal media; objective characterization; regions of interest; Attenuation measurement; Backscatter; Extracellular; In vitro; In vivo; Lesions; Lipidomics; Radiofrequency identification; Ultrasonic imaging; Ultrasonic variables measurement;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Ultrasonics Symposium, 1996. Proceedings., 1996 IEEE
Conference_Location :
San Antonio, TX
ISSN :
1051-0117
Print_ISBN :
0-7803-3615-1
Type :
conf
DOI :
10.1109/ULTSYM.1996.584176
Filename :
584176
Link To Document :
بازگشت