Title :
A tomographic simulation technique for evaluating quantitative limitations of myocardial PET studies
Author :
Hutchins, Gary D. ; Caraher, John ; Murphy, Brian ; Wolfe, Ed ; Schwaiger, Markus
Author_Institution :
Div. of Nucl. Med., Michigan Univ., MI, USA
Abstract :
A three-dimensional simulation method has been developed for evaluating the potential to quantify myocardial function with PET (positron emission tomography) using a three-dimensional beating heart phantom. Expected tracer kinetics are assigned regionally throughout the heart phantom and tomographic simulation methods are utilized to form a dynamic sequence of images. Analysis of the simulated data using standard kinetic evaluation tools provides estimates of bias and variance in the kinetic parameters as a function of emission and transmission scan statistics, image scatter fraction, and placement of regions of interest. Comparison of the simulation results with measured PET data demonstrates the validity of the simulation approach and its application in the evaluation of quantitative myocardial PET studies.<>
Keywords :
cardiology; computerised tomography; modelling; muscle; radioisotope scanning and imaging; 3D beating heart phantom; image scatter fraction; myocardial PET studies; nuclear medicine dynamic image sequence; positron emission tomography; quantitative limitations; regions of interest placement; tomographic simulation technique; tracer kinetics; transmission scan statistics; Analysis of variance; Analytical models; Heart; Image analysis; Imaging phantoms; Kinetic theory; Myocardium; Positron emission tomography; Scattering parameters; Statistical analysis;
Conference_Titel :
Nuclear Science Symposium and Medical Imaging Conference, 1991., Conference Record of the 1991 IEEE
Conference_Location :
Santa Fe, NM, USA
Print_ISBN :
0-7803-0513-2
DOI :
10.1109/NSSMIC.1991.259179
