Photothermal nanoblade for single cell surgery and large cargo delivery

Author

Ting-Hsiang Wu ; Teslaa, T. ; Teitell, Michael A. ; Pei-Yu Chiou

Author_Institution

Dept. of Mech. & Aerosp. Eng., UCLA, Los Angeles, CA, USA

fYear

2011

fDate

8-11 Aug. 2011

Firstpage

57

Lastpage

58

Abstract

We report a photothermal nanoblade that utilizes a metallic nanostructure to harvest short laser pulse energy to generate highly localized explosive vapor bubbles for rapid cell membrane cutting. The cavitation bubble pattern is controlled by the metallic structure configuration, laser pulse duration and energy. Integrating the metallic nanostructure with a micropipette, the nanoblade can generate a micron-sized membrane access port for large cargo delivery with high efficiency (46%) and cell viability (>;90%) into mammalian cells [1,2].

Keywords

biomembranes; bubbles; cellular biophysics; integrated optics; laser applications in medicine; laser beam cutting; micro-optics; nanobiotechnology; nanophotonics; nanostructured materials; surgery; cavitation bubble pattern; cell viability; large cargo delivery; localized explosive vapor bubbles; mammalian cells; metallic nanostructure; micron-sized membrane; micropipette; photothermal nanoblade; rapid cell membrane cutting; short laser pulse energy; single cell surgery;

fLanguage

English

Publisher

ieee

Conference_Titel

Optical MEMS and Nanophotonics (OMN), 2011 International Conference on

Conference_Location

Istanbul

ISSN

2160-5033

Print_ISBN

978-1-4577-0334-8

Type

conf

DOI

10.1109/OMEMS.2011.6031074

Filename

6031074