Title :
Factor analysis of dynamic structures (FADS) for quantitative modelling of positron emission tomographic (PET) image sequences
Author :
Cinotti, L. ; Le Bars, D. ; Landais, P. ; Millet, P. ; Frouin, F. ; Di Paola, R.
Abstract :
Summary form only given, as follows. From positron emission tomography (PET) image sequences it is possible to estimate biological parameters by means of measurements inside regions of interest. Several compartments, with various contributions, are present in each region. FADS automatically provides factors (kinetics corresponding to a pure compartment), factor images (spatial distribution of the factor), and their respective contributions. Using three radioisotopes with different decay time constants to simulate biological kinetics, mixed in various proportions in several vials, the authors validated FADS for (1) the number of kinetics and the expected time constants, (2) the spatial distribution of the compartments, and (3) the percentage of isotopes in each vial.<>
Keywords :
computerised tomography; image sequences; medical image processing; modelling; radioisotope scanning and imaging; PET images sequences; biological kinetics simulation; biological parameters estimation; decay time constants; factor images; factor spatial distribution; medical diagnostic imaging; nuclear medicine; positron emission tomography; quantitative modelling; time constants; vial; Bars; Biological system modeling; Image sequences; Isotopes; Kinetic theory; Parameter estimation; Positron emission tomography; Radioactive decay; Radioactive materials;
Conference_Titel :
Nuclear Science Symposium and Medical Imaging Conference, 1991., Conference Record of the 1991 IEEE
Conference_Location :
Santa Fe, NM, USA
Print_ISBN :
0-7803-0513-2
DOI :
10.1109/NSSMIC.1991.259206
