Title :
A high-throughput biosensor for detection and quantification of protein induced DNA bending
Author :
Xirui Zhang ; Spuhler, P. ; Unlu, M.S. ; Sola, L. ; Chiari, M.
Author_Institution :
Dept. of Biomed. Eng., Boston Univ., Boston, MA, USA
Abstract :
The functions of genes depend on interactions with DNA-binding proteins. DNA bends or kinks upon specific binding with proteins. This biosensor measures binding-induced conformational changes of DNA in a high-throughput manner with sub-nanometer accuracy.
Keywords :
DNA; biosensors; genetics; molecular biophysics; molecular configurations; proteins; DNA bending; DNA binding protein; conformational change; gene function; high throughput biosensor; protein detection; protein quantification; DNA binding protein; high-throughput biosensor; sub-nanometer;
Conference_Titel :
Optical MEMS and Nanophotonics (OMN), 2011 International Conference on
Conference_Location :
Istanbul
Print_ISBN :
978-1-4577-0334-8
DOI :
10.1109/OMEMS.2011.6031106
