Title :
Acute HIV detection by viral lysate impedance spectroscopy on a microchip
Author :
Shafiee, H. ; Jahangir, M. ; Inci, Fatih ; Wang, Shuhui ; Willingbrecht, R. ; Guigel, F.F. ; Kuritzkes, D.R. ; Demirci, Utkan
Author_Institution :
Med. Sch., Dept. of Med., Harvard Univ., Boston, MA, USA
Abstract :
Detecting acute Human Immunodeficiency Virus (HIV-1) at the point-of-care (POC) is an unmet clinical need. Current POC detection methods such as dipsticks and OraQuick detect antibodies and not the intact virus. These methods are not effective due the low concentration of antibodies [1, 2]. Infected persons with acute HIV-1 can potentially transmit the infection because they are not aware of their disease [3, 4]. Rapid and inexpensive POC detection diagnostic tool to detect acute HIV-1 can potentially have a substantial effect on preventing HIV-1 transmission through people at high risk of HIV-1.
Keywords :
bioelectric phenomena; biomedical equipment; diseases; microorganisms; microsensors; molecular biophysics; patient diagnosis; proteins; HIV-1 transmission prevention; POC detection diagnostic tool; acute HIV-1 detection; disease; human immunodeficiency virus; infection transmission; microchip; point of care; viral lysate impedance spectroscopy; Dielectrophoresis; Human immunodeficiency virus; Impedance; Medical diagnostic imaging; Pathogens; Spectroscopy; Acute HIV-1; biosensing; electrical sensing; microfluidics;
Conference_Titel :
Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS & EUROSENSORS XXVII), 2013 Transducers & Eurosensors XXVII: The 17th International Conference on
Conference_Location :
Barcelona
DOI :
10.1109/Transducers.2013.6627225
