Acute HIV detection by viral lysate impedance spectroscopy on a microchip

Author

Shafiee, H. ; Jahangir, M. ; Inci, Fatih ; Wang, Shuhui ; Willingbrecht, R. ; Guigel, F.F. ; Kuritzkes, D.R. ; Demirci, Utkan

Author_Institution

Med. Sch., Dept. of Med., Harvard Univ., Boston, MA, USA

fYear

2013

fDate

16-20 June 2013

Firstpage

2141

Lastpage

2144

Abstract

Detecting acute Human Immunodeficiency Virus (HIV-1) at the point-of-care (POC) is an unmet clinical need. Current POC detection methods such as dipsticks and OraQuick detect antibodies and not the intact virus. These methods are not effective due the low concentration of antibodies [1, 2]. Infected persons with acute HIV-1 can potentially transmit the infection because they are not aware of their disease [3, 4]. Rapid and inexpensive POC detection diagnostic tool to detect acute HIV-1 can potentially have a substantial effect on preventing HIV-1 transmission through people at high risk of HIV-1.

Keywords

bioelectric phenomena; biomedical equipment; diseases; microorganisms; microsensors; molecular biophysics; patient diagnosis; proteins; HIV-1 transmission prevention; POC detection diagnostic tool; acute HIV-1 detection; disease; human immunodeficiency virus; infection transmission; microchip; point of care; viral lysate impedance spectroscopy; Dielectrophoresis; Human immunodeficiency virus; Impedance; Medical diagnostic imaging; Pathogens; Spectroscopy; Acute HIV-1; biosensing; electrical sensing; microfluidics;

fLanguage

English

Publisher

ieee

Conference_Titel

Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS & EUROSENSORS XXVII), 2013 Transducers & Eurosensors XXVII: The 17th International Conference on

Conference_Location

Barcelona

Type

conf

DOI

10.1109/Transducers.2013.6627225

Filename

6627225