Title :
Active control of silicon nanotweezers detects enzymatic reaction at the molecular level
Author :
Lafitte, Nicolas ; Haddab, Yassine ; Le Gorrec, Yann ; Guillou, Herve ; Kumemura, Momoko ; Jalabert, Laurent ; Collard, Dominique ; Fujita, Hideaki
Author_Institution :
LIMMS, Univ. of Tokyo, Tokyo, Japan
Abstract :
This work has achieved the control of micromachined tweezers for the enhancement of the sensing of DNA molecules. The tool allows a routine trapping of the molecules and the real-time monitoring of the mechanical properties of the bundle of molecules. Monitoring the resonance response of the system, the bundle and the interactions of enzymes or proteins are characterized. Furthermore the design and the implementation of state feedback decrease the equivalent stiffness of the system and improve the sensitivity of the tool.
Keywords :
DNA; biosensors; elemental semiconductors; enzymes; nanosensors; nanostructured materials; proteins; silicon; DNA molecule sensing; Si; active control; enzymatic reaction; enzymes; equivalent stiffness; mechanical properties; micromachined tweezers; molecular level; proteins; real-time monitoring; resonance response; routine trapping; silicon nanotweezers; tool sensitivity; Biochemistry; DNA; Nanobioscience; Resonant frequency; Sensitivity; Silicon; State feedback; DNA; HindIII; Nanotweezers; control; restriction enzymes; sensitivity improvement;
Conference_Titel :
Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS & EUROSENSORS XXVII), 2013 Transducers & Eurosensors XXVII: The 17th International Conference on
Conference_Location :
Barcelona
DOI :
10.1109/Transducers.2013.6627279
