Title :
Nanoplasmonic biosensing platform for multiple pathogen detection
Author :
Inci, Fatih ; Tokel, O. ; Wang, Shuhui ; Gurkan, U.A. ; Kuritzkes, D.R. ; Demirci, Utkan
Author_Institution :
Med. Sch., Dept. of Med., Harvard Univ., Boston, MA, USA
Abstract :
In this study, we present for the first time a reliable, fast, accurate and sensitive multiple pathogen detection platforms that can be adapted to the point-of-care (POC) in resource-constrained settings. Here, nanoplasmonic properties of metal nanoparticles are utilized to detect the captured viruses on the biosensing surface, and the platform also allows to report a quantitative viral load for HIV-infected anonymous discarded patient whole blood samples. The limit of detection covers the definition of treatment failure indicated by World Health Organization (WHO) (viral load (VL)>5,000 copies/mL) and the Department of Health and Human Services (DHHS) and AIDS Clinical Trials Group (ACTG) (VL>200 copies/mL).
Keywords :
biosensors; microorganisms; nanoparticles; plasmonics; HIV infected anonymous discarded patient; World Health Organization; biosensing surface; metal nanoparticles; multiple pathogen detection; nanoplasmonic biosensing platform; point-of-care; resource constrained settings; viral load; whole blood samples; Biosensors; Blood; Human immunodeficiency virus; Monitoring; Nanoparticles; Pathogens; Viruses (medical); HIV; Nanoplasmonic; pathogen detection assays; point-of-care; viral load;
Conference_Titel :
Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS & EUROSENSORS XXVII), 2013 Transducers & Eurosensors XXVII: The 17th International Conference on
Conference_Location :
Barcelona
DOI :
10.1109/Transducers.2013.6627297
