A flexible, laser-defined, paper platform for localized oxygen generation and delivery

Author

Ochoa, M. ; Rahimi, R. ; Alemdar, N. ; Dokmeci, M.R. ; Khademhosseini, Ali ; Ziaie, Babak

Author_Institution

Purdue Univ., West Lafayette, IN, USA

fYear

2013

fDate

16-20 June 2013

Firstpage

2712

Lastpage

2715

Abstract

A flexible, parchment paper/PDMS based platform for local wound oxygenation was fabricated and characterized. The platform consists of a PDMS microfluidic network bonded to a parchment paper substrate. Generation of oxygen occurs by flowing H₂O₂ through the channels and chemically decomposing it via a catalyst embedded in laser-defined regions of the parchment paper. PDMS was bonded to parchment paper using partially cured PDMS followed by air plasma, resulting in a strong bond (323 Torr). For pressures below 110 Torr the parchment paper was observed to be impermeable to water. The measured gas permeability of parchment paper was 1.42 μL/ (Torr · mm² · min). Oxygen generation in the catalyst spots raised the oxygen level on the opposite side of the parchment paper from atmospheric levels to 25.6%. Device and material biocompatibility with NIH 3T3 fibroblast cells was confirmed via alamar blue assays.

Keywords

biomedical materials; catalysts; decomposition; hydrogen compounds; laser materials processing; microfluidics; oxygen; paper; patient treatment; permeability; polymers; H₂O₂; NIH 3T3 fibroblast cell; O₂; PDMS; air plasma; alamar blue assay; biocompatibe material; flexible platform; gas permeability; laser defined platform; laser defined region; local wound oxygenation; localized oxygen delivery; localized oxygen generation; microfluidic network; paper platform; parchment paper; Lasers; Microchannel; Oxygen; Permeability; Plasmas; Substrates; Wounds; Oxygen generation; parchment paper; wound healing;

fLanguage

English

Publisher

ieee

Conference_Titel

Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS & EUROSENSORS XXVII), 2013 Transducers & Eurosensors XXVII: The 17th International Conference on

Conference_Location

Barcelona

Type

conf

DOI

10.1109/Transducers.2013.6627366

Filename

6627366