Extracellular signal-regulated kinase activation in mechanically stimulated adult rat cardiac fibroblasts

Author

Summerour, Sonya R. ; Villarreal, Francisco J. ; McCulloch, Andrew D.

Author_Institution

Dept. of Bioeng., California Univ., San Diego, La Jolla, CA, USA

Volume

1

fYear

1999

fDate

1999

Abstract

We examined extracellular-signal regulated kinase (ERK) activity in adult rat cardiac fibroblasts (CF´s) in response to tensile and compressive strains. Our equibiaxial stretch apparatus was utilized to apply mechanical stretch (1%, 4%, 6% and 10%) and compression (-6%) to cultured CF´s. Whereas equibiaxial stretching of CFs activated ERK in a time-dependent manner, compression led to inhibition of ERK activation. Thus, mechanical stretch and compression appear to be effective, differential regulators of ERK signaling in CF´s

Keywords

biological techniques; biomechanics; biomembrane transport; cardiology; molecular biophysics; proteins; compressive strain; differential regulators; equibiaxial stretch apparatus; equibiaxial stretching; extracellular signal-regulated kinase activation; extracellular-signal regulated kinase activation; extracellular-signal regulated kinase activity; extracellular-signal regulated kinase signalling; inhibition; mechanical stretch; mechanically stimulated adult rat cardiac fibroblasts; tensile strain; time-dependent manner; Biomedical engineering; Biomembranes; Capacitive sensors; Extracellular; Fibroblasts; Heart; In vitro; Mechanical factors; Proteins; Tensile strain;

fLanguage

English

Publisher

ieee

Conference_Titel

[Engineering in Medicine and Biology, 1999. 21st Annual Conference and the 1999 Annual Fall Meetring of the Biomedical Engineering Society] BMES/EMBS Conference, 1999. Proceedings of the First Joint

Conference_Location

Atlanta, GA

ISSN

1094-687X

Print_ISBN

0-7803-5674-8

Type

conf

DOI

10.1109/IEMBS.1999.802039

Filename

802039