Cyclic pressure affects bone cell proliferation

Success of load-bearing dental/orthopedic implants relies on appropriate integration of the surrounding tissues at the interface. Following surgically induced trauma, bone tissue at the implant site undergoes a healing/regeneration process, which involves multiple cell types. Although the general sequence of wound healing is well known, the cellular/molecular-level responses to mechanical loading at the bone-implant interface are still poorly understood. In order to elucidate some of the events taking place during bone healing/remodeling under mechanical loading, the present study used in vitro cellular models and investigated and compared the effects of cyclic pressure on the proliferation of osteoblasts, fibroblasts and endothelial cells