DocumentCode
346787
Title
Genetically engineered non-osteoblastic cells expressing a transcriptional activator of osteoblast differentiation
Author
Byers, B.A. ; Pavlath, G.K. ; García, A.J.
Author_Institution
Sch. of Mech. Eng., Georgia Inst. of Technol., Atlanta, GA, USA
Volume
1
fYear
1999
fDate
1999
Abstract
In order to investigate alternative methods for the development of a tissue-engineered bone graft, this research focuses on forced expression of Osf2, an osteoblast-specific transcriptional activator, in 293 cells. Results indicate that, upon transfection, these non-osteoblastic cells express the Osf2 gene product and, therefore, maybe induced to express the osteoblastic phenotype
Keywords
bone; cellular biophysics; genetics; genetically engineered nonosteoblastic cells; osteoblast differentiation; osteoblastic phenotype; tissue-engineered bone graft; transcriptional activator; transfection; Bones; Dentistry; Fibroblasts; Fluorescence; Genetic engineering; Immune system; Mechanical engineering; Mineralization; Orthopedic surgery; Proteins;
fLanguage
English
Publisher
ieee
Conference_Titel
[Engineering in Medicine and Biology, 1999. 21st Annual Conference and the 1999 Annual Fall Meetring of the Biomedical Engineering Society] BMES/EMBS Conference, 1999. Proceedings of the First Joint
Conference_Location
Atlanta, GA
ISSN
1094-687X
Print_ISBN
0-7803-5674-8
Type
conf
DOI
10.1109/IEMBS.1999.802150
Filename
802150
Link To Document