Title :
Factors affecting chondrocyte phenotype during monolayer expansion
Author :
Malaviya, P. ; Yamaoto, S. ; Nerem, R M
Author_Institution :
Inst. of Bioeng., Georgia Inst. of Technol., Atlanta, GA, USA
Abstract :
Primary bovine articular chondrocyte (BAC) monolayers were treated with fluid shear (0.5 Pa) and hypoxia (5% O2) and compared with monolayers grown under static normoxic conditions. Results indicate that shear stress and hypoxia reverse chondrocyte dedifferentiation observed under static normoxic conditions
Keywords :
biorheology; cellular biophysics; monolayers; O2; chondrocyte dedifferentiation reversal; chondrocyte phenotype; fluid shear; hypoxia; monolayer expansion; primary bovine articular chondrocyte monolayers; static normoxic conditions; Biomedical engineering; Bioreactors; Bovine; Polymers; Postal services; Protein engineering; RNA; Stress; Tellurium; Tissue engineering;
Conference_Titel :
[Engineering in Medicine and Biology, 1999. 21st Annual Conference and the 1999 Annual Fall Meetring of the Biomedical Engineering Society] BMES/EMBS Conference, 1999. Proceedings of the First Joint
Conference_Location :
Atlanta, GA
Print_ISBN :
0-7803-5674-8
DOI :
10.1109/IEMBS.1999.802153
