Suppression of beat to beat repolarization variability by electrical coupling in guinea pig ventricular myocytes

Author

Spitzer, Kenneth W. ; Zaniboni, Massimiliano ; Yang, Lin ; Pollard, Andrew E.

Author_Institution

Cardiovascular Res. & Training Inst., Utah Univ., Salt Lake City, UT, USA

Volume

1

fYear

1999

fDate

1999

Abstract

To examine relationships between intracellular coupling and cardiac repolarization, we electrically connected isolated guinea pig ventricular myocytes to one another with a junctional resistance. Because coupling was achieved by an external circuit that supplied coupling current based solely on transmembrane potential difference, cell-to-cell interactions were considered in their simplest form, independent of ionic diffusion via gap junctions or mechanical interactions between cells

Keywords

bioelectric potentials; biological techniques; biomembrane transport; cardiology; muscle; beat to beat repolarization variability; cardiac repolarization; cell-to-cell interactions; coupling current; electrical coupling; external circuit; intracellular coupling; isolated guinea pig ventricular myocytes; junctional resistance; transmembrane potential difference; Biology; Calcium; Cardiology; Cities and towns; Computer simulation; Coupling circuits; Delay; Management training; Physiology; Rectifiers;

fLanguage

English

Publisher

ieee

Conference_Titel

[Engineering in Medicine and Biology, 1999. 21st Annual Conference and the 1999 Annual Fall Meetring of the Biomedical Engineering Society] BMES/EMBS Conference, 1999. Proceedings of the First Joint

Conference_Location

Atlanta, GA

ISSN

1094-687X

Print_ISBN

0-7803-5674-8

Type

conf

DOI

10.1109/IEMBS.1999.802193

Filename

802193