Existence of bistability and correlation with arrhythmogenesis in sheep atria

Author

Oliver, Robert A. ; Krassowska, Wanda ; Hall, G. Martin ; Bahar, Sonya ; Wolf, Patrick D. ; Gauthier, Daniel J.

Author_Institution

Duke Univ., Durham, NC, USA

Volume

1

fYear

1999

fDate

1999

Abstract

This experimental study investigates the response of sheep atria to periodic pacing. In 23 trials over 6 animals, a window of bistability was observed wherein for a range of pacing periods the atria responded 1:1 or 2:1 depending on whether pacing period was increasing or decreasing. In 18 trials, non-paced activations were also observed. In 17 of those 18 trials, the non-paced activations occurred at pacing periods within or no more than 30 ms away from the window of bistability. These results suggest bistability exists in cardiac tissue and is correlated with arrhythmogenesis

Keywords

bioelectric phenomena; cardiology; 30 ms; arrhythmogenesis; bistability; cardiac electrophysiology; nonpaced activations; pacing period; periodic pacing; sheep atria; Animals; Animation; Biomedical engineering; Cardiac tissue; Electrodes; Extracellular; Heart; Hysteresis; In vivo; Switches;

fLanguage

English

Publisher

ieee

Conference_Titel

[Engineering in Medicine and Biology, 1999. 21st Annual Conference and the 1999 Annual Fall Meetring of the Biomedical Engineering Society] BMES/EMBS Conference, 1999. Proceedings of the First Joint

Conference_Location

Atlanta, GA

ISSN

1094-687X

Print_ISBN

0-7803-5674-8

Type

conf

DOI

10.1109/IEMBS.1999.802201

Filename

802201