Nitric oxide monitoring in hippocampal brain slices

Author

Rangarajan, R. ; Johnson, L.J. ; Yang, N.C. ; Thakor, N.V.

Author_Institution

Dept. of Biomed. Eng., Johns Hopkins Univ. Sch. of Med., Baltimore, MD, USA

Volume

1

fYear

1999

fDate

1999

Abstract

Nitric Oxide (NO) is known to mediate the excitotoxic injury caused due to overactivation of N-Methyl-D-Aspartate (NMDA) receptors. NO production in response to NMDA receptor activation is studied in three hippocampal subregions: the CA1, CA3 and the Dentate Gyrus (DG). These three regions are differentially sensitive to NMDA toxicity, with the degree of response being the highest in CA1 and the lowest in DG. The results show that the NO production in these regions is different and consistent with their sensitivity to NMDA

Keywords

biochemistry; brain; monitoring; nitrogen compounds; CA1; CA3; N-methyl-D-aspartate receptors overactivation; NMDA toxicity; NO; dentate gyrus; differentially sensitive regions; excitotoxic injury; hippocampal brain slices; nitric oxide monitoring; Biomedical engineering; Biomedical monitoring; Biosensors; Brain; Computer aided instruction; Electrodes; Hippocampus; Injuries; Neurons; Production;

fLanguage

English

Publisher

ieee

Conference_Titel

[Engineering in Medicine and Biology, 1999. 21st Annual Conference and the 1999 Annual Fall Meetring of the Biomedical Engineering Society] BMES/EMBS Conference, 1999. Proceedings of the First Joint

Conference_Location

Atlanta, GA

ISSN

1094-687X

Print_ISBN

0-7803-5674-8

Type

conf

DOI

10.1109/IEMBS.1999.802442

Filename

802442