Title :
Modification of evoked responses in cultured cortical networks
Author :
Jimbo, Yasuhiko ; Torimitsu, Keiichi
Author_Institution :
NTT Basic Res. Labs., Kanagawa, Japan
Abstract :
Activity-dependent modification of evoked activity was studied using cultured cortical networks on electrode-array substrates. The novel multi-site stimulation system enabled the authors to observe pathway-specific enhancement and depression of network activity simultaneously induced by a single tetanus. Correlation analysis revealed that this bidirectional modification followed a common rule: how closely the individual pathways were correlated with the tetanized pathway
Keywords :
bioelectric potentials; biological specimen preparation; brain; neural nets; neurophysiology; bidirectional modification; correlation analysis; electrode-array substrates; network activity depression; pathway-specific enhancement; single tetanus; tetanized pathway; Disk recording; Electrodes; Embryo; Hard disks; Information processing; Intelligent networks; Laboratories; Monitoring; Neural networks; Neurons;
Conference_Titel :
[Engineering in Medicine and Biology, 1999. 21st Annual Conference and the 1999 Annual Fall Meetring of the Biomedical Engineering Society] BMES/EMBS Conference, 1999. Proceedings of the First Joint
Conference_Location :
Atlanta, GA
Print_ISBN :
0-7803-5674-8
DOI :
10.1109/IEMBS.1999.802448
