Biocompatibility of chronically implanted polymer-based intrafascicular electrodes

Author

Lawrence, S.M. ; Larsen, J.O. ; Horch, K.W. ; Riso, R. ; Sinkjaer, T.

Author_Institution

Dept. of Bioeng., Utah Univ., Salt Lake City, UT, USA

Volume

1

fYear

1999

fDate

1999

Abstract

The authors implanted 11 polymer-based intrafascicular electrodes into the peroneal and/or tibial branches of the right sciatic nerve in 8 New Zealand white rabbits for a period of 6 months where the contralateral limb served as the control. The fiber diameter distributions, myelin thickness, and axon counts were measured at the level of the implant, 1.5 cm proximally, and 1.5 cm distally. PolyLIFEs caused no significant effect on axon counts or diameter, but induced slight demyelination distal to the implant. Encapsulation of the implants was also minimal

Keywords

biomedical electrodes; neurophysiology; polymers; prosthetics; 1.5 cm; 6 month; New Zealand white rabbits; biocompatibility; chronically implanted polymer-based intrafascicular electrodes; fiber diameter distribution; implant encapsulation; myelin thickness; neuroprosthetics; peroneal branch; polyLIFEs; right sciatic nerve; slight demyelination; tibial branch; Biomedical engineering; Electrodes; Implants; Nerve fibers; Optical fiber testing; Polymers; Rabbits; Sampling methods; Signal restoration; Thickness control;

fLanguage

English

Publisher

ieee

Conference_Titel

[Engineering in Medicine and Biology, 1999. 21st Annual Conference and the 1999 Annual Fall Meetring of the Biomedical Engineering Society] BMES/EMBS Conference, 1999. Proceedings of the First Joint

Conference_Location

Atlanta, GA

ISSN

1094-687X

Print_ISBN

0-7803-5674-8

Type

conf

DOI

10.1109/IEMBS.1999.802451

Filename

802451