Title :
Brain dynamics: coupling intrinsic and synaptic processes
Author :
Skinner, Frances K.
Author_Institution :
Dept. of Med. & Physiol., Toronto Western Hosp. Univ., Ont., Canada
Abstract :
A parametric model of a two-cell interneuronal network has been developed to understand the genesis and control of slow bursting oscillations observed in rat brain slices. The model suggests that a mechanism underlying this behaviour involves persistent sodium and slowly inactivating potassium currents coupled with inhibitory synapses and gap junctions between the neurons. Larger networks as well as more realistic neuronal models are being developed within the context of this mechanism
Keywords :
bioelectric phenomena; brain models; cellular transport; physiological models; potassium; K; Na; brain dynamics; gap junctions; inhibitory synapses; intrinsic processes; parametric model; persistent sodium currents; rat brain slices; realistic neuronal models; slow bursting oscillations; slowly inactivating potassium currents; synaptic processes; two-cell interneuronal network; Biological neural networks; Brain modeling; Context modeling; Hippocampus; Hospitals; Nervous system; Neurons; Parametric statistics; Physiology; Rhythm;
Conference_Titel :
[Engineering in Medicine and Biology, 1999. 21st Annual Conference and the 1999 Annual Fall Meetring of the Biomedical Engineering Society] BMES/EMBS Conference, 1999. Proceedings of the First Joint
Conference_Location :
Atlanta, GA
Print_ISBN :
0-7803-5674-8
DOI :
10.1109/IEMBS.1999.802484
