Title :
A wireless chemical sensing scheme using ultrasonic imaging of microbubble embeded hydrogel
Author :
Park, J.H. ; Kim, A. ; Song, S.H. ; Bhandari, P. ; Irudayaraj, J. ; Ziaie, B.
Author_Institution :
Birck Nanotechnol. Center, Purdue Univ., West Lafayette, IN, USA
Abstract :
In this paper, we demonstrate a wireless chemical sensing scheme using ultrasonic imaging of a microbubble-functionalized hydrogel, which we call “bubblegel.” By incorporating oxygen microbubbles into a hydrogel, its volume transition, which is responsive to its chemical microenvironment, can be wirelessly monitored by ultrasonic imaging; measuring volume directly or measuring the reflected acoustic intensity from the surface of the bubblegel. Here a bubblegel fabricated with pH-sensitive poly (methacrylic acid-co-acrylamide) hydrogel is investigated in vitro. The sensor shows a sensitivity of 19.49 gray-scale intensity/pH and a resolution of 0.25 pH unit in the linear response region (between pH 4 and 6). It is expected that the concept can be adapted to hydrogels sensitive to other stimuli (e.g., glucose, biomarkers, etc.).
Keywords :
bubbles; chemical sensors; hydrogels; oxygen; ultrasonic imaging; wireless sensor networks; bubblegel; chemical microenvironment; linear response region; microbubble embedded hydrogel; microbubble-functionalized hydrogel; oxygen microbubbles; pH-sensitive poly (methacrylic acid-co-acrylamide) hydrogel; reflected acoustic intensity; ultrasonic imaging; volume transition; wireless chemical sensing scheme; Acoustics; Chemicals; Gray-scale; Polymers; Sensors; Ultrasonic imaging; Wireless sensor networks; Chemical Sensor; Hydrogel; Ultrasonic Imaging;
Conference_Titel :
Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS), 2015 Transducers - 2015 18th International Conference on
Conference_Location :
Anchorage, AK
DOI :
10.1109/TRANSDUCERS.2015.7181402