Title :
Nitric oxide releasing materials for the prevention of thrombosis and restenosis
Author :
Bohl, K.S. ; West, J.L.
Author_Institution :
Dept. of Bioeng., Rice Univ., Houston, TX, USA
Abstract :
The goal of the current study was to synthesize biofunctional polymers that spontaneously release nitric oxide under physiological conditions. Such materials may have applications for the prevention of thrombosis and restenosis following arterial injury. We have synthesized two hydrogels that release nitric oxide (NO) with different release kinetics. There was evidence of NO release over a period of several weeks from NO-nucleophile complexes within hydrogels, while S-nitrosocysteine hydrogels displayed NO release over several hours
Keywords :
biomedical materials; gels; nitrogen compounds; photochemistry; polymer blends; polymerisation; NO; NO-nucleophile complexes; S-nitrosocysteine hydrogels; arterial injury; biofunctional polymers; copolymer; hydrogels; nitric oxide releasing materials; photopolymerisation; physiological conditions; release kinetics; restenosis prevention; spontaneous NO release; synthesis; thrombosis prevention; Amino acids; Arteries; Biological materials; Biomedical engineering; Injuries; Kinetic theory; Material storage; Muscles; Polymers; Thrombosis;
Conference_Titel :
[Engineering in Medicine and Biology, 1999. 21st Annual Conference and the 1999 Annual Fall Meetring of the Biomedical Engineering Society] BMES/EMBS Conference, 1999. Proceedings of the First Joint
Conference_Location :
Atlanta, GA
Print_ISBN :
0-7803-5674-8
DOI :
10.1109/IEMBS.1999.803874
