Title :
Photocrosslinkable hyaluronic acid for cell encapsulation
Author :
Smeds, Kimberly A. ; Burnett, D.R. ; Hatchell, Diane L. ; Pfister-Serres, A. ; Grinstaff, Mark W.
Author_Institution :
Dept. of Chem., Duke Univ., Durham, NC, USA
Abstract :
The microencapsulation of human or animal islets of Langerhans cells, which contain the insulin producing beta cells, in crosslinked polymers has been investigated for the treatment of diabetes. We have developed a modified hyaluronic acid biopolymer for islet cell encapsulation that possesses several advantages over previous systems. The physical and chemical properties of these photocrosslinked microcapsules have been characterized and preliminary in vitro and in vivo experiments of islet cell encapsulation have been initiated
Keywords :
biodiffusion; biomedical materials; cellular transport; encapsulation; photochemistry; polymer blends; polymerisation; Langerhans cells; animal islets; cell encapsulation; chemical properties; crosslinked polymers; diabetes treatment; diffusion; human islets; in vitro experiments; in vivo experiments; insulin producing beta cells; metabolic control; microencapsulation; modified hyaluronic acid biopolymer; photocrosslinkable hyaluronic acid; photocrosslinked microcapsules; physical properties; transplantation; Calcium; Chemicals; Diabetes; Encapsulation; Immune system; In vivo; Insulin; Pancreas; Polymers; Sugar;
Conference_Titel :
[Engineering in Medicine and Biology, 1999. 21st Annual Conference and the 1999 Annual Fall Meetring of the Biomedical Engineering Society] BMES/EMBS Conference, 1999. Proceedings of the First Joint
Conference_Location :
Atlanta, GA
Print_ISBN :
0-7803-5674-8
DOI :
10.1109/IEMBS.1999.803879
